A comparison of gene expression profiles of rat tissues after mild and short-term calorie restrictions

Kenji Saito, Maiko Ito, Takuya Chiba, Huijuan Jia, Hisanori Kato*

*この研究の対応する著者

研究成果: Article査読

抄録

Many studies have shown the beneficial effects of calorie restriction (CR) on rodents’ aging; however, the molecular mechanism explaining these beneficial effects is still not fully understood. Previously, we conducted transcriptomic analysis on rat liver with short-term and mild-to-moderate CR to elucidate its early response to such diet. Here, we expanded transcriptome analysis to muscle, adipose tissue, intestine, and brain and compared the gene expression profiles of these multiple organs and of our previous dataset. Several altered gene expressions were found, some of which known to be related to CR. Notably, the commonly regulated genes by CR include nicotinamide phosphoribosyltransferase and heat shock protein 90, which are involved in declining the aging process and thus potential therapeutic targets for aging-related diseases. The data obtained here provide information on early response markers and key mediators of the CR-induced delay in aging as well as on age-associated pathological changes in mammals.

本文言語English
論文番号2277
ジャーナルNutrients
13
7
DOI
出版ステータスPublished - 2021 7

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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