A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning

Naoki Masuda*, Shun Ichi Amari

*この研究の対応する著者

研究成果: Article査読

22 被引用数 (Scopus)

抄録

There is a debate regarding whether motor memory is stored in the cerebellar cortex, or the cerebellar nuclei, or both. Memory may be acquired in the cortex and then be transferred to the cerebellar nuclei. Based on a dynamical system modeling with a minimal set of variables, we theoretically investigated possible mechanisms of memory transfer and consolidation in the context of vestibulo-ocular reflex learning. We tested different plasticity rules for synapses in the cerebellar nuclei and took robustness of behavior against parameter variation as the criterion of plausibility of a model variant. In the most plausible scenarios, mossy-fiber nucleus-neuron synapses or Purkinje-cell nucleus-neuron synapses are plastic on a slow time scale and store permanent memory, whose content is passed from the cerebellar cortex storing transient memory. In these scenarios, synaptic strengths are potentiated when the mossy-fiber afferents to the nuclei are active during a pause in Purkinje-cell activities. Furthermore, assuming that mossy fibers create a limited variety of signals compared to parallel fibers, our model shows partial memory transfer from the cortex to the nuclei.

本文言語English
ページ(範囲)137-156
ページ数20
ジャーナルJournal of Computational Neuroscience
24
2
DOI
出版ステータスPublished - 2008 4
外部発表はい

ASJC Scopus subject areas

  • 感覚系
  • 認知神経科学
  • 細胞および分子神経科学

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