A concise synthetic approach to optically active taxol C-ring fragment

Masahisa Nakada, Ei Ichi Kojima, Yukitaka Iwata

研究成果: Article

17 引用 (Scopus)

抄録

A concise synthetic approach to an optically active taxol C-ring fragment starting from a readily available compound is described. Lewis acid promoted-cyclization of optically active epoxy trimethylsilane 7 affords the key intermediate 8 in 69% yield (at 91% conversion). Further transformation of 8 to our taxol C-ring fragment is successfully achieved in a stereoselective manner.

元の言語English
ページ(範囲)313-316
ページ数4
ジャーナルTetrahedron Letters
39
発行部数3-4
DOI
出版物ステータスPublished - 1998 1 15
外部発表Yes

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Paclitaxel
Lewis Acids
Cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

これを引用

A concise synthetic approach to optically active taxol C-ring fragment. / Nakada, Masahisa; Kojima, Ei Ichi; Iwata, Yukitaka.

:: Tetrahedron Letters, 巻 39, 番号 3-4, 15.01.1998, p. 313-316.

研究成果: Article

Nakada, Masahisa ; Kojima, Ei Ichi ; Iwata, Yukitaka. / A concise synthetic approach to optically active taxol C-ring fragment. :: Tetrahedron Letters. 1998 ; 巻 39, 番号 3-4. pp. 313-316.
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