A concise synthetic approach to optically active taxol C-ring fragment

Masahisa Nakada, Ei Ichi Kojima, Yukitaka Iwata

研究成果: Article

17 引用 (Scopus)

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A concise synthetic approach to an optically active taxol C-ring fragment starting from a readily available compound is described. Lewis acid promoted-cyclization of optically active epoxy trimethylsilane 7 affords the key intermediate 8 in 69% yield (at 91% conversion). Further transformation of 8 to our taxol C-ring fragment is successfully achieved in a stereoselective manner.

元の言語English
ページ(範囲)313-316
ページ数4
ジャーナルTetrahedron Letters
39
発行部数3-4
DOI
出版物ステータスPublished - 1998 1 15

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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