A cyanobacterial gene encoding an ortholog of Pirin is induced under stress conditions

Yukako Hihara*, Masayuki Muramatsu, Kinu Nakamura, Kintake Sonoike

*この研究の対応する著者

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Pirin is a recently identified protein in eukaryotes as a transcription cofactor or as an apoptosis-related protein. Although Pirin is highly conserved from bacteria to human, there have been no reports on prokaryotic Pirin orthologs. We show here that pirA (sll1773) encoding an ortholog of Pirin together with an adjacent gene, pirB (ssl3389), was upregulated under high salinity and some other stress conditions in a cyanobacterium Synechocystis sp. PCC 6803. Induction of the pirAB genes was not related to cell death and disruption of pirA did not affect the gene expression profile. Expression of the pirAB genes was negatively regulated by a LysR family transcriptional regulator encoded by pirR (slr1871) located immediately upstream of pirAB in the divergent direction. DNA microarray analysis indicated that PirR repressed expression of closely located ORFs, slr1870 and mutS (sll1772), in addition to pirAB and pirR itself.

本文言語English
ページ(範囲)101-105
ページ数5
ジャーナルFEBS Letters
574
1-3
DOI
出版ステータスPublished - 2004 9 10
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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