A cyclic AMP-regulated negative feedforward system for neuritogenesis revealed in a neuroblastoma × glioma hybrid cell line

T. Tojima, E. Ito*

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We examined the role of second messengers during the neuritogenesis that accompanies neuronal differentiation in a neuroblastoma × glioma hybrid cell line (NG108-15). NG108-15 cells extended neurites after treatment with dibutyryl cyclic AMP. This dibutyryl cyclic AMP treatment evoked the synthesis of voltage-dependent Ca2+ channel proteins in the cells. The number of neurites was decreased by Ca2+ influx under condition of high K+. Interestingly, the increase of neurites stimulated by dibutyryl cyclic AMP and the decrease of neurites caused by high K+ were both reversible. This is the first study to demonstrate that cyclic AMP regulates a negative feedforward system for neuritogenesis, which links with Ca2+ signaling. Such a dual role of cyclic AMP may play an important part in precise neurite targeting.

本文言語English
ページ(範囲)583-591
ページ数9
ジャーナルNeuroscience
104
2
DOI
出版ステータスPublished - 2001 5 10
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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