抄録
We examined the role of second messengers during the neuritogenesis that accompanies neuronal differentiation in a neuroblastoma × glioma hybrid cell line (NG108-15). NG108-15 cells extended neurites after treatment with dibutyryl cyclic AMP. This dibutyryl cyclic AMP treatment evoked the synthesis of voltage-dependent Ca2+ channel proteins in the cells. The number of neurites was decreased by Ca2+ influx under condition of high K+. Interestingly, the increase of neurites stimulated by dibutyryl cyclic AMP and the decrease of neurites caused by high K+ were both reversible. This is the first study to demonstrate that cyclic AMP regulates a negative feedforward system for neuritogenesis, which links with Ca2+ signaling. Such a dual role of cyclic AMP may play an important part in precise neurite targeting.
本文言語 | English |
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ページ(範囲) | 583-591 |
ページ数 | 9 |
ジャーナル | Neuroscience |
巻 | 104 |
号 | 2 |
DOI | |
出版ステータス | Published - 2001 5月 10 |
外部発表 | はい |
ASJC Scopus subject areas
- 神経科学(全般)