抄録
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 + dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 600-605 |
| ページ数 | 6 |
| ジャーナル | Nature |
| 巻 | 565 |
| 発行部数 | 7741 |
| DOI | |
| 出版物ステータス | Published - 2019 1 31 |
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ASJC Scopus subject areas
- General
これを引用
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. / Tanoue, Takeshi; Morita, Satoru; Plichta, Damian R.; Skelly, Ashwin N.; Suda, Wataru; Sugiura, Yuki; Narushima, Seiko; Vlamakis, Hera; Motoo, Iori; Sugita, Kayoko; Shiota, Atsushi; Takeshita, Kozue; Yasuma-Mitobe, Keiko; Riethmacher, Dieter; Kaisho, Tsuneyasu; Norman, Jason M.; Mucida, Daniel; Suematsu, Makoto; Yaguchi, Tomonori; Bucci, Vanni; Inoue, Takashi; Kawakami, Yutaka; Olle, Bernat; Roberts, Bruce; Hattori, Masahira; Xavier, Ramnik J.; Atarashi, Koji; Honda, Kenya.
：: Nature, 巻 565, 番号 7741, 31.01.2019, p. 600-605.研究成果: Article
}
TY - JOUR
T1 - A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
AU - Tanoue, Takeshi
AU - Morita, Satoru
AU - Plichta, Damian R.
AU - Skelly, Ashwin N.
AU - Suda, Wataru
AU - Sugiura, Yuki
AU - Narushima, Seiko
AU - Vlamakis, Hera
AU - Motoo, Iori
AU - Sugita, Kayoko
AU - Shiota, Atsushi
AU - Takeshita, Kozue
AU - Yasuma-Mitobe, Keiko
AU - Riethmacher, Dieter
AU - Kaisho, Tsuneyasu
AU - Norman, Jason M.
AU - Mucida, Daniel
AU - Suematsu, Makoto
AU - Yaguchi, Tomonori
AU - Bucci, Vanni
AU - Inoue, Takashi
AU - Kawakami, Yutaka
AU - Olle, Bernat
AU - Roberts, Bruce
AU - Hattori, Masahira
AU - Xavier, Ramnik J.
AU - Atarashi, Koji
AU - Honda, Kenya
PY - 2019/1/31
Y1 - 2019/1/31
N2 - There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 + dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.
AB - There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 + dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85060753155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060753155&partnerID=8YFLogxK
U2 - 10.1038/s41586-019-0878-z
DO - 10.1038/s41586-019-0878-z
M3 - Article
C2 - 30675064
AN - SCOPUS:85060753155
VL - 565
SP - 600
EP - 605
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7741
ER -