A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Takeshi Tanoue, Satoru Morita, Damian R. Plichta, Ashwin N. Skelly, Wataru Suda, Yuki Sugiura, Seiko Narushima, Hera Vlamakis, Iori Motoo, Kayoko Sugita, Atsushi Shiota, Kozue Takeshita, Keiko Yasuma-Mitobe, Dieter Riethmacher, Tsuneyasu Kaisho, Jason M. Norman, Daniel Mucida, Makoto Suematsu, Tomonori Yaguchi, Vanni BucciTakashi Inoue, Yutaka Kawakami, Bernat Olle, Bruce Roberts, Masahira Hattori, Ramnik J. Xavier, Koji Atarashi, Kenya Honda

研究成果: Article

52 引用 (Scopus)

抄録

There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 + dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.

元の言語English
ページ(範囲)600-605
ページ数6
ジャーナルNature
565
発行部数7741
DOI
出版物ステータスPublished - 2019 1 31

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Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
Listeria monocytogenes
Feces
Dendritic Cells
Interferons
Intestines
Neoplasms
Inflammation
Therapeutics
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • General

これを引用

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., ... Honda, K. (2019). A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature, 565(7741), 600-605. https://doi.org/10.1038/s41586-019-0878-z

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. / Tanoue, Takeshi; Morita, Satoru; Plichta, Damian R.; Skelly, Ashwin N.; Suda, Wataru; Sugiura, Yuki; Narushima, Seiko; Vlamakis, Hera; Motoo, Iori; Sugita, Kayoko; Shiota, Atsushi; Takeshita, Kozue; Yasuma-Mitobe, Keiko; Riethmacher, Dieter; Kaisho, Tsuneyasu; Norman, Jason M.; Mucida, Daniel; Suematsu, Makoto; Yaguchi, Tomonori; Bucci, Vanni; Inoue, Takashi; Kawakami, Yutaka; Olle, Bernat; Roberts, Bruce; Hattori, Masahira; Xavier, Ramnik J.; Atarashi, Koji; Honda, Kenya.

:: Nature, 巻 565, 番号 7741, 31.01.2019, p. 600-605.

研究成果: Article

Tanoue, T, Morita, S, Plichta, DR, Skelly, AN, Suda, W, Sugiura, Y, Narushima, S, Vlamakis, H, Motoo, I, Sugita, K, Shiota, A, Takeshita, K, Yasuma-Mitobe, K, Riethmacher, D, Kaisho, T, Norman, JM, Mucida, D, Suematsu, M, Yaguchi, T, Bucci, V, Inoue, T, Kawakami, Y, Olle, B, Roberts, B, Hattori, M, Xavier, RJ, Atarashi, K & Honda, K 2019, 'A defined commensal consortium elicits CD8 T cells and anti-cancer immunity', Nature, 巻. 565, 番号 7741, pp. 600-605. https://doi.org/10.1038/s41586-019-0878-z
Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y その他. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019 1 31;565(7741):600-605. https://doi.org/10.1038/s41586-019-0878-z
Tanoue, Takeshi ; Morita, Satoru ; Plichta, Damian R. ; Skelly, Ashwin N. ; Suda, Wataru ; Sugiura, Yuki ; Narushima, Seiko ; Vlamakis, Hera ; Motoo, Iori ; Sugita, Kayoko ; Shiota, Atsushi ; Takeshita, Kozue ; Yasuma-Mitobe, Keiko ; Riethmacher, Dieter ; Kaisho, Tsuneyasu ; Norman, Jason M. ; Mucida, Daniel ; Suematsu, Makoto ; Yaguchi, Tomonori ; Bucci, Vanni ; Inoue, Takashi ; Kawakami, Yutaka ; Olle, Bernat ; Roberts, Bruce ; Hattori, Masahira ; Xavier, Ramnik J. ; Atarashi, Koji ; Honda, Kenya. / A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. :: Nature. 2019 ; 巻 565, 番号 7741. pp. 600-605.
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