A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes

Fernando López-Redondo, Junko Kurokawa, Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Tetsushi Furukawa, Kenji Yasuda

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We investigated electrophysiological properties of human induced-pluripotent-stem-cell-derived and embryonic-stem-cell-derived cardiomyocytes, and analyzed action potential parameters by plotting their frequency distributions. In the both cell lines, the distribution analysis revealed that histograms of maximum upstroke velocity showed two subpopulations with similar intersection values. Sub-populations with faster maximum upstroke velocity showed significant prolongation of action potential durations by application of E-4031, whereas others did not, which may be partly due to shallower maximum diastolic potentials. We described electrophysiological and pharmacological properties of stem-cell-derived cardiomyocytes in the respective sub-populations, which provides a way to characterize diverse electrical properties of stem-cell-derived cardiomyocytes systematically.

本文言語English
ページ(範囲)141-145
ページ数5
ジャーナルJournal of Pharmacological Sciences
131
2
DOI
出版ステータスPublished - 2016 6 1
外部発表はい

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

フィンガープリント 「A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル