A fit-fat index for predicting incident diabetes in apparently healthy men: A prospective cohort study

Robert A. Sloan, Benjamin A. Haaland, Susumu Sawada, I. Min Lee, Xuemei Sui, Duck Chul Lee, Yassine Ridouane, Falk Müller-Riemenschneider, Steven N. Blair

研究成果: Article

8 引用 (Scopus)

抜粋

Background: The purpose of this study was to examine the impact of combined cardiorespiratory fitness and waist-to-height ratio in the form of a fit-fat index on incident diabetes risk. Additionally, the independent predictive performance of cardiorespiratory fitness, waist-to-height ratio, and body mass index also were estimated and compared. Methods: This was a prospective cohort study of 10,381 men who had a normal electrocardiogram and no history of major chronic disease at baseline from 1979 to 2005. Random survival forest models and traditional Cox proportional hazards models were used to predict diabetes at 5-, 10-, and 15-year incidence horizons. Results: Overall, 4.8% of the participants developed diabetes. Receiver operating characteristic curve analyses for incidence risk demonstrated good discrimination using random survival forest models across fitness and fatness measures; Cox models were poor to fair. The differences between fitness and fatness measures across horizons were clinically negligible. Smoothed random survival forest estimates demonstrated the impact of each fitness and fatness measure on incident diabetes was intuitive and graded. Conclusions: Although fitness and fatness measures showed a similar discriminative ability in predicting incident diabetes, unique to the study was the ability of the fit-fat index to demonstrate a better indication of incident risk when compared to fitness or fatness alone. A single index combining cardiorespiratory fitness and waist-to-height ratio may be more useful because it can indicate improvements in either or both of the measures.

元の言語English
記事番号e0157703
ジャーナルPLoS One
11
発行部数6
DOI
出版物ステータスPublished - 2016 6 1
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

フィンガープリント A fit-fat index for predicting incident diabetes in apparently healthy men: A prospective cohort study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Sloan, R. A., Haaland, B. A., Sawada, S., Lee, I. M., Sui, X., Lee, D. C., Ridouane, Y., Müller-Riemenschneider, F., & Blair, S. N. (2016). A fit-fat index for predicting incident diabetes in apparently healthy men: A prospective cohort study. PLoS One, 11(6), [e0157703]. https://doi.org/10.1371/journal.pone.0157703