For realizing better trade-off between performance and yield rate in recent LSI designs, it is required to deal with increasing the ratios of interconnect delay as well as delay variation. In this paper, a novel floorplan-aware high-level synthesis technique with delay-variation tolerance is proposed. By utilizing floorplan-driven architectures, interconnect delays can be estimated and then handled even in high-level synthesis. Applying our technique enables to realize two scheduling/binding results (one is a non-delayed result and the other is a delayed result) simultaneously on a chip with small area/performance overhead, and either one of them can be selected according to the post-silicon delay variation. Experimental results demonstrate that our technique can reduce delayed scheduling/binding latency by up to 32.3% compared with conventional approaches.