A genetic study of inositol trisphosphate involvement in phototransduction using Drosophila mutants

Hiroko Inoue, Tohru Yoshioka, Yoshiki Hotta

研究成果: Article査読

57 被引用数 (Scopus)

抄録

Phosphatidylinositol 4,5-bisphosphate phosphodiesterase activity was found to be almost absent in the compound eyes of Drosophila visual mutant, norpA (no receptor potentials A). We compared the enzyme activities among independently isolated norpA alleles, each having a different degree of the vision defect. A close correlation was found between the size of receptor potentials (electroretinogram), phototactic behavior and the enzyme activity. The correlation exists not only among alleles, but also in a single, temperature-dependent allele under different temperature; the enzyme activity of flies kept at 18°C (phototactic) was about five times higher than that of the ones kept at 28°C (blind). These results suggest that hydrolysis of phosphatidylinositol 4,5-bisphosphate is involved in phototransduction process in Drosophila eyes.

本文言語English
ページ(範囲)513-519
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
132
2
DOI
出版ステータスPublished - 1985 10 30
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 分子生物学

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