A highly stereoselective intramolecular Diels-Alder reaction for construction of the AB ring moiety of bruceantin

Kenji Usui, Takahiro Suzuki, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

A highly stereoselective intramolecular Diels-Alder (IMDA) reaction for the construction of the AB ring moiety of bruceantin is described. The product of the IMDA reaction comprises a trans-AB ring junction and stereotetrad including an all carbon quaternary stereogenic center, wherein three stereogenic centers correspond to those of bruceantin. Functional groups embedded in the product are suitable for a variety of transformations. Hence, this IMDA product could be a useful intermediate for the enantioselective total synthesis of not only bruceantin, but also other bioactive compounds.

本文言語English
ページ(範囲)1247-1251
ページ数5
ジャーナルTetrahedron Letters
56
10
DOI
出版ステータスPublished - 2015 3月 4

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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