A highly stereoselective intramolecular Diels-Alder reaction for construction of the AB ring moiety of bruceantin

Kenji Usui, Takahiro Suzuki, Masahisa Nakada

研究成果: Article

6 引用 (Scopus)

抜粋

A highly stereoselective intramolecular Diels-Alder (IMDA) reaction for the construction of the AB ring moiety of bruceantin is described. The product of the IMDA reaction comprises a trans-AB ring junction and stereotetrad including an all carbon quaternary stereogenic center, wherein three stereogenic centers correspond to those of bruceantin. Functional groups embedded in the product are suitable for a variety of transformations. Hence, this IMDA product could be a useful intermediate for the enantioselective total synthesis of not only bruceantin, but also other bioactive compounds.

元の言語English
ページ(範囲)1247-1251
ページ数5
ジャーナルTetrahedron Letters
56
発行部数10
DOI
出版物ステータスPublished - 2015 3 4

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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