A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism

Rei Kadota, Kazuma Sugita, Kenko Uchida, Hitoshi Yamada, Masashi Yamashita, Hidenori Kimura*

*この研究の対応する著者

    研究成果: Article査読

    5 被引用数 (Scopus)

    抄録

    Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.

    本文言語English
    ページ(範囲)213-223
    ページ数11
    ジャーナルJournal of Theoretical Biology
    456
    DOI
    出版ステータスPublished - 2018 11月 7

    ASJC Scopus subject areas

    • 統計学および確率
    • モデリングとシミュレーション
    • 生化学、遺伝学、分子生物学(全般)
    • 免疫学および微生物学(全般)
    • 農業および生物科学(全般)
    • 応用数学

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