A novel gene isolated from human placenta located in down syndrome critical region on chromosome 21

Akiko Nakamura, Masahira Hattori, Yoshiyuki Sakaki

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Down syndrome is the most common birth defect, which is caused by trisomy 21. We identified a novel gene in the so-called Down syndrome critical region by EST mapping to genomic DNA and following cDNA cloning. The gene, designated DCRB (Down syndrome Critical Region gene B), consisted of three exons of 1095 bp in total and encoded a large open reading frame of 118 amino acid residues. The amino acids sequence of DCRB showed no significant homology to any known protein. Northern blot analysis showed that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band were detected. Minor bands of 1.4 kb and 2.2 kb were also detected in adult heart and skeletal muscle.

本文言語English
ページ(範囲)321-324
ページ数4
ジャーナルDNA Research
4
5
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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