A novel methodology to evaluate health impacts caused by VOC exposures using real-time VOC and Holter monitors

Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Yukio Yanagisawa

研究成果: Article

16 引用 (Scopus)

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While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effrects to relate their values to the personal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions. The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating a suppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system.

元の言語English
ページ(範囲)4127-4138
ページ数12
ジャーナルInternational journal of environmental research and public health
7
発行部数12
DOI
出版物ステータスPublished - 2010 12 1

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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