A novel mouse monoclonal antibody targeting ErbB2 suppresses breast cancer growth

Seiji Kawa, Hirohisa Matsushita, Hirokazu Ohbayashi, Kentaro Semba, Tadashi Yamamoto

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Overexpression of ErbB2 in breast cancer is associated with increased recurrence and worse prognosis. Accumulating evidences suggest that molecular targeted therapy is a promising anticancer strategy. In this study, we produced a novel anti-ErbB2 monoclonal antibody, 6G10, that recognized an epitope distinct from the trastuzumab binding site. 6G10 induced aggregation of BT474 breast cancer cells and inhibited proliferation of various breast cancer cell lines including BT474. A growth inhibition assay showed that 6G10 had EC50 values comparable to trastuzumab, indicating that the drugs have a similar level of potency. Furthermore, intraperitoneal administration of 6G10 completely inhibited the growth of xenografted tumors derived from BT474 and SK-BR-3 cells. These data suggested that 6G10 has great therapeutic potential and could be administered to patients alternatively, or synergistically, with trastuzumab.

本文言語English
ページ(範囲)329-333
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
384
3
DOI
出版ステータスPublished - 2009 7 3

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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