A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection

Masafumi Noguchi*, Eisuke Aoki, Daiki Yoshida, Etsuko Kobayashi, Shigeru Omori, Yoshihiro Muragaki, Hiroshi Iseki, Katsushige Nakamura, Ichiro Sakuma

*この研究の対応する著者

研究成果: Conference contribution

抄録

We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 urn close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.

本文言語English
ホスト出版物のタイトルLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ページ543-550
ページ数8
4190 LNCS - I
出版ステータスPublished - 2006
外部発表はい
イベント9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen
継続期間: 2006 10 12006 10 6

出版物シリーズ

名前Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
4190 LNCS - I
ISSN(印刷版)03029743
ISSN(電子版)16113349

Other

Other9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
CityCopenhagen
Period06/10/106/10/6

ASJC Scopus subject areas

  • コンピュータ サイエンス(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 理論的コンピュータサイエンス

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