A pentose bisphosphate pathway for nucleoside degradation in Archaea

Riku Aono, Takaaki Sato, Tadayuki Imanaka, Haruyuki Atomi*

*この研究の対応する著者

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.

本文言語English
ページ(範囲)355-360
ページ数6
ジャーナルNature Chemical Biology
11
5
DOI
出版ステータスPublished - 2015 5月 1
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

フィンガープリント

「A pentose bisphosphate pathway for nucleoside degradation in Archaea」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル