A population balance model for solvent-mediated polymorphic transformation in unseeded solutions

M. Kobari, N. Kubota, I. Hirasawa

研究成果: Article

7 被引用数 (Scopus)

抄録

A new population balance model for solvent-mediated polymorphic transformation is presented. The model takes into account the secondary nucleation caused by nuclei grown crystals as well as the primary nucleation. Numerical simulation was performed for crystallization of a hypothetical enantiotropic dimorphic compound in an unseeded solution. In the simulation, particular attention was paid to the effect of secondary nucleation of the stable polymorph on the transformation time. The simulated transformation time decreased with an increase in the secondary nucleation rate of the stable polymorph. Reported experimental data on the effect of stirrer speed were explained by the secondary nucleation-mediated mechanism, in which the secondary nucleation rate is assumed to increase with an increase in stirrer speed. The effect of scale-up on the transformation time was also suggested to be explained by the secondary nucleation-mediated mechanism.

本文言語English
ページ(範囲)6049-6058
ページ数10
ジャーナルCrystEngComm
16
27
DOI
出版ステータスPublished - 2014 7 21

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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