A protonic biotransducer controlling mitochondrial ATP synthesis

Z. Zhang, H. Kashiwagi, S. Kimura, S. Kong, Y. Ohta*, T. Miyake


研究成果: Article査読

6 被引用数 (Scopus)


In nature, protons (H+) play an important role in biological activities such as in mitochondrial ATP synthesis, which is driven by a H+ gradient across the inner membrane, or in the activation of acid sensing ion channels in neuron cells. Bioprotonic devices directly interface with the H+ concentration (pH) to facilitate engineered interactions with these biochemical processes. Here we develop a H+ biotransducer that changes the pH in a mitochondrial matrix by controlling the flow of H+ between a conductive polymer of sulfonated polyaniline and solution. We have successfully modulated the rate of ATP synthesis in mitochondria by altering the solution pH. Our H+ biotransducer provides a new way to monitor and modulate pH dependent biological functions at the interface between the electronic devices and biological materials.

ジャーナルScientific reports
出版ステータスPublished - 2018 12月 1

ASJC Scopus subject areas

  • 一般


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