A simple supramolecular complex of boronic acid-appended β-cyclodextrin and a fluorescent boronic acid-based probe with excellent selectivity for d-glucose in water

Ko Sugita, Yota Suzuki, Yuji Tsuchido, Shoji Fujiwara, Takeshi Hashimoto*, Takashi Hayashita

*この研究の対応する著者

研究成果: Article査読

抄録

Various diboronic acid-based chemosensors for d-glucose have been developed for use in diabetes diagnostic systems. However, most of these chemosensors have limitations, such as poor water solubility, difficulties in synthesis, and inability to selectively detect d-glucose from among other saccharides. We report a simple chemosensor based on a supramolecular complex of fluorophenylboronic acid-appended β-cyclodextrin (FPB-βCyD) and an anthracene-based probe having a boronic acid moiety (1). Hydrophobic 1 is encapsulated in the cyclodextrin cavity of FPB-βCyD, making the supramolecular complex (1/FPB-βCyD) applicable in a water-rich solvent mixture (98% water). Interestingly, 1/FPB-βCyD showed a strong turn-on response to d-glucose with a 9.6-fold enhancement in fluorescence intensity, and no response to other saccharides. This study uncovers an innovative approach based on the supramolecular assembly of simple components for the development of a water-soluble d-glucose chemosensor with excellent selectivity.

本文言語English
ページ(範囲)20259-20263
ページ数5
ジャーナルRSC Advances
12
31
DOI
出版ステータスPublished - 2022 7月 14

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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