A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Prapatsorn Techawanitchai*, Naokazu Idota, Koichiro Uto, Mitsuhiro Ebara, Takao Aoyagi

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We demonstrate a timed explosive drug release from smart pH-responsive hydrogels by utilizing a phototriggered spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (o-NBA) was integrated into poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) hydrogels. o-NBA-hydrogels demonstrated the rapid release of protons upon UV irradiation, allowing the pH inside the gel to decrease to below the pKa value of P(NIPAAm-co-CIPAAm). The generated protons diffused gradually toward the non-illuminated area, and the diffusion kinetics could be controlled by adjusting the UV irradiation time and intensity. After irradiation, we observed the enhanced release of entrapped L-3,4- dihydroxyphenylalanine (DOPA) from the gels, which was driven by the dissociation of DOPA from CIPAAm. Local UV irradiation also triggered the release of DOPA from the non-illuminated area in the gel via the diffusion of protons. Conventional systems can activate only the illuminated region, and their response is discontinuous when the light is turned off. The ability of the proposed pH-jump system to permit gradual activation via proton diffusion may be beneficial for the design of predictive and programmable devices for drug delivery.

本文言語English
論文番号064202
ジャーナルScience and Technology of Advanced Materials
13
6
DOI
出版ステータスPublished - 2012 12月
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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