A strategy for C-H activation of pyridines: Direct C-2 selective alkenylation of pyridines by Nickel/Lewis acid catalysis

Yoshiaki Nakao, Kyalo Stephen Kanyiva, Tamejiro Hiyama

研究成果: Article査読

334 被引用数 (Scopus)

抄録

The C-2 selective alkenylation of pyridine derivatives is achieved with a catalyst consisting of nickel and Lewis acid. Use of diorganozinc compounds as the Lewis acid catalyst gives C-2 monoalkenylation products, whereas AlMe3 changes the reaction course to afford C-2 dienylated products, which are derived from double insertion of alkynes into the C(2)-H bond. The reaction demonstrates a broad substrate scope and proceeds with high chemo-, regio-, and stereoselectivities under mild conditions compared with previous examples of direct C-H functionalization of pyridines.

本文言語English
ページ(範囲)2448-2449
ページ数2
ジャーナルJournal of the American Chemical Society
130
8
DOI
出版ステータスPublished - 2008 2 27
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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