A temperature-compensated model for circadian rhythms that can be entrained by temperature cycles

Tsutomu Takeuchi, Takamichi Hinohara, Gen Kurosawa, Kenko Uchida*

*この研究の対応する著者

    研究成果査読

    19 被引用数 (Scopus)

    抄録

    From the viewpoint that reaction rates will change with temperature, we present a general method to build circadian clock models that generate circadian oscillations with almost constant period under different constant ambient temperature, and propose an algorithm estimating the parameter condition for compensated period against the change of temperature based on the PER single-feedback loop model of Goldbeter [1995. A model for circadian oscillations in the Drosophila period protein (PER). Proc. R. Soc. London Ser. B 261, 319-324] for Drosophila. We show that the model with derived parameters can realize the temperature compensation over a wide range of temperature, and simultaneously can realize the entrainment to temperature cycles.

    本文言語English
    ページ(範囲)195-204
    ページ数10
    ジャーナルJournal of Theoretical Biology
    246
    1
    DOI
    出版ステータスPublished - 2007 5 7

    ASJC Scopus subject areas

    • 農業および生物科学(全般)

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