A twin study of rheumatoid arthritis in the Japanese population

Chikashi Terao*, Katsunori Ikari, Shingo Nakayamada, Yusuke Takahashi, Ryo Yamada, Koichiro Ohmura, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Shinji Yoshida, Kazuyoshi Saito, Atsuo Taniguchi, Shigeki Momohara, Hisashi Yamanaka, Tsuneyo Mimori, Fumihiko Matsuda

*この研究の対応する著者

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Objectives: Rheumatoid arthritis (RA) is the most common immune-related inflammatory arthritis affecting 0.5–1.0% of the population. Both genetic and environmental factors are associated with RA onset. Twin studies reported from European countries estimated heritability of RA as 53–65%. However, no twin studies have been reported from Asian countries. Methods: We collected a total of 43 monozygotic and 43 dizygotic twins from 7550 patients with RA and obtained information of RA status in the twin pairs. We characterized RA patients whose twin siblings had RA. Variance components analysis was performed to estimate heritability in RA in the Japanese population. Results: Four and one patients with RA over 43 monozygotic (9.3%) and 43 dizygotic twins (2.3%), respectively, had twin siblings with RA. All the patients whose information of sero-positivity was available and whose twin siblings had RA were sero-positive. Heritability of RA was estimated as 62.2% and 56.1% in the AE and ACE models, respectively. The estimated heritability was comparable with those reported in the Europeans, compatible with previous overlap of RA susceptibility genes between Japanese and European populations. Conclusions: Heritability of RA onset in the Japanese population is estimated to be comparable with that in European populations.

本文言語English
ページ(範囲)685-689
ページ数5
ジャーナルModern Rheumatology
26
5
DOI
出版ステータスPublished - 2016 9月 2
外部発表はい

ASJC Scopus subject areas

  • リウマチ学

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