A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2

Ryuichi Murakami, Kaori Denda-Nagai, Shin ichi Hashimoto, Shigenori Nagai, Masahira Hattori, Tatsuro Irimura

研究成果: Article

46 引用 (Scopus)

抄録

Dendritic cell (DC) subsets in the skin and draining lymph nodes (LNs) are likely to elicit distinct immune response types. In skin and skin-draining LNs, a dermal DC subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b) was found distinct from migratory Langerhans cells (LCs) or CD103+ dermal DCs (dDCs). Lower expression levels of Th1-promoting and/or cross-presentation-related molecules were suggested by the transcriptome analysis and verified by the quantitative real-time PCR analysis in MGL2+ dDCs than in CD103+ dDCs. Transfer of MGL2+ dDCs but not CD103+ dDCs from FITC-sensitized mice induced a Th2-type immune response in vivo in a model of contact hypersensitivity. Targeting MGL2+ dDCs with a rat monoclonal antibody against MGL2 efficiently induced a humoral immune response with Th2-type properties, as determined by the antibody subclass. We propose that the properties of MGL2+ dDCs, are complementary to those of CD103+ dDCs and skew the immune response toward a Th2-type response.

元の言語English
記事番号e73270
ジャーナルPLoS One
8
発行部数9
DOI
出版物ステータスPublished - 2013 9 9
外部発表Yes

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Langerhans Cells
dendritic cells
Skin
immune response
lymph nodes
Langerhans cells
C-Type Lectins
Fluorescein-5-isothiocyanate
Macrophages
transcriptomics
Galactose
humoral immunity
hypersensitivity
lectins
galactose
Rats
monoclonal antibodies
quantitative polymerase chain reaction
macrophages
Monoclonal Antibodies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

これを引用

Murakami, R., Denda-Nagai, K., Hashimoto, S. I., Nagai, S., Hattori, M., & Irimura, T. (2013). A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2. PLoS One, 8(9), [e73270]. https://doi.org/10.1371/journal.pone.0073270

A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2. / Murakami, Ryuichi; Denda-Nagai, Kaori; Hashimoto, Shin ichi; Nagai, Shigenori; Hattori, Masahira; Irimura, Tatsuro.

:: PLoS One, 巻 8, 番号 9, e73270, 09.09.2013.

研究成果: Article

Murakami, R, Denda-Nagai, K, Hashimoto, SI, Nagai, S, Hattori, M & Irimura, T 2013, 'A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2', PLoS One, 巻. 8, 番号 9, e73270. https://doi.org/10.1371/journal.pone.0073270
Murakami, Ryuichi ; Denda-Nagai, Kaori ; Hashimoto, Shin ichi ; Nagai, Shigenori ; Hattori, Masahira ; Irimura, Tatsuro. / A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2. :: PLoS One. 2013 ; 巻 8, 番号 9.
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