A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2

Ryuichi Murakami, Kaori Denda-Nagai, Shin ichi Hashimoto, Shigenori Nagai, Masahira Hattori, Tatsuro Irimura

研究成果: Article査読

55 被引用数 (Scopus)

抄録

Dendritic cell (DC) subsets in the skin and draining lymph nodes (LNs) are likely to elicit distinct immune response types. In skin and skin-draining LNs, a dermal DC subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b) was found distinct from migratory Langerhans cells (LCs) or CD103+ dermal DCs (dDCs). Lower expression levels of Th1-promoting and/or cross-presentation-related molecules were suggested by the transcriptome analysis and verified by the quantitative real-time PCR analysis in MGL2+ dDCs than in CD103+ dDCs. Transfer of MGL2+ dDCs but not CD103+ dDCs from FITC-sensitized mice induced a Th2-type immune response in vivo in a model of contact hypersensitivity. Targeting MGL2+ dDCs with a rat monoclonal antibody against MGL2 efficiently induced a humoral immune response with Th2-type properties, as determined by the antibody subclass. We propose that the properties of MGL2+ dDCs, are complementary to those of CD103+ dDCs and skew the immune response toward a Th2-type response.

本文言語English
論文番号e73270
ジャーナルPLoS One
8
9
DOI
出版ステータスPublished - 2013 9 9
外部発表はい

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

フィンガープリント 「A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル