Absolute structure and anti-oxidative activity of chaetochiversin c isolated from fungal strain neocosmospora sp. Fki-7792 by physicochemical screening

Hirotaka Matsuo*, Tomoyasu Hirose, Takayuki Mokudai, Kenichi Nonaka, Yoshimi Niwano, Toshiaki Sunazuka, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

*この研究の対応する著者

研究成果: Article査読

抄録

A new chaetochiversin analog, designated chaetochiversin C (1), was discovered from a cul-tured broth of fungal strain FKI-7792 by physico-chemical screening. This strain was identified as a member of genus Neocosmospora based on mor-phology and DNA barcoding. The partially relative configuration of 1 was determined by13C-NMR chemical shifts of the acetonide analog of 1. The absolute configuration was determined using an advanced Mosher’s method. Compound 1 was as-sessed for anti-tumor, anti-microbial, and anti-malarial activities, and its ability to scavenge or quench reactive oxygen species (ROS), such as superoxide anion radicals, hydroxy radicals and singlet oxygen (1O2 ). Compound 1 showed a quenching effect on1O2.

本文言語English
ページ(範囲)181-187
ページ数7
ジャーナルJournal of General and Applied Microbiology
66
3
DOI
出版ステータスPublished - 2020
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 応用微生物学とバイオテクノロジー

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