Acemannan used as an implantable biomaterial for vital pulp therapy of immature permanent teeth induced continued root formation

Tien Thuy Vu, Minh Truong Nguyen, Polkit Sangvanich, Quang Ngoc Nguyen, Pasutha Thunyakitpisal

研究成果: Article査読

抄録

Direct pulp-capping, a vital pulp therapy, is used to protect and preserve pulp vitality by applying a biomaterial on the pulp exposure site. Acemannan, a polysaccharide extracted from Aloe vera, induces osteodentin-bridge formation to cover the exposure site in vivo. We evaluated the effect of acemannan sponges on partial pulpotomized permanent teeth with caries or accident-induced pulp exposure (n = 50). After removing infected dentin and inflamed pulp tissue, the teeth were randomly divided into acemannan or control (mineral trioxide aggregate (MTA) groups (n = 25). The teeth were examined immediately after treatment (baseline) and at 6-and 12-month follow-ups for clinical and cone beam computed tomography (CBCT) examination. The three-dimensional tooth length and root apex area were simulated to determine treatment success. We found that the overall success rate in the acemannan and MTA groups from baseline to 12-month follow-up was 90.91% and 95.65%, respectively, with no significant difference between the two groups (p > 0.05). In the success teeth in both groups, the root length increased, and the apex area significantly decreased (p < 0.05), indicating continued root formation. Our results suggest that acemannan is a promising low-cost biomaterial for partial pulpotomy treatment for immature permanent teeth requiring vital pulp therapy.

本文言語English
論文番号644
ページ(範囲)1-16
ページ数16
ジャーナルPharmaceutics
12
7
DOI
出版ステータスPublished - 2020 7

ASJC Scopus subject areas

  • Pharmaceutical Science

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