Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters

Shinji Fukuda, Hidehiro Toh, Todd D. Taylor, Hiroshi Ohno*, Masahira Hattori

*この研究の対応する著者

研究成果: Article査読

107 被引用数 (Scopus)

抄録

The human gut harbors a large and diverse community of commensal bacteria. Among them, Bifidobacterium is known to exhibit various probiotic effects including protection of hosts from infectious diseases. We recently discovered that genes encoding an ATPbinding- cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting gnotobiotic mice from death induced by enterohemorrhagic Escherichia coli O157:H7. We elucidated the molecular mechanism on lethal infection in mice associated with several bifidobacterial strains by a multiomics approach combining genomics, transcriptomics and metabolomics. The combined data clearly show that acetate produced by protective bifidobacteria acts in vivo to promote defense functions of the host epithelial cells and thereby protects the host from lethal infection. As demonstrated here, our multi-omics approach provides a powerful strategy for evaluation of host-microbial interactions in the complex gut ecosystem.

本文言語English
ジャーナルGut Microbes
3
5
DOI
出版ステータスPublished - 2012 1 1
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 消化器病学
  • 微生物学(医療)
  • 感染症

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