Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis

Arimasa Matsumoto, Hanae Ozaki, Sumeru Tsuchiya, Toru Asahi, Meir Lahav, Tsuneomi Kawasaki, Kenso Soai

研究成果: Article

1 引用 (Scopus)

抄録

Chiral crystals of the only achiral proteinogenic α-amino acid, glycine induced the asymmetric autocatalysis with amplification of enantiomeric excess (ee). The P3 1 crystals of γ-glycine, which display positive Cotton effect (CD) at around 215 nm, mediate the asymmetric autocatalysis to yield (R)-pyrimidyl alkanol with high ee. In contrast, the enantiomorphic P3 2 crystals, which display negative Cotton effect, afford (S)-alkanol after the significant amplification of ee by asymmetric autocatalysis.

元の言語English
ページ(範囲)4200-4203
ページ数4
ジャーナルOrganic and Biomolecular Chemistry
17
発行部数17
DOI
出版物ステータスPublished - 2019 1 1

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autocatalysis
glycine
Glycine
amino acids
cotton
Amino Acids
Crystals
Cotton
Amplification
crystals

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

これを引用

Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis. / Matsumoto, Arimasa; Ozaki, Hanae; Tsuchiya, Sumeru; Asahi, Toru; Lahav, Meir; Kawasaki, Tsuneomi; Soai, Kenso.

:: Organic and Biomolecular Chemistry, 巻 17, 番号 17, 01.01.2019, p. 4200-4203.

研究成果: Article

Matsumoto, A, Ozaki, H, Tsuchiya, S, Asahi, T, Lahav, M, Kawasaki, T & Soai, K 2019, 'Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis', Organic and Biomolecular Chemistry, 巻. 17, 番号 17, pp. 4200-4203. https://doi.org/10.1039/c9ob00345b
Matsumoto, Arimasa ; Ozaki, Hanae ; Tsuchiya, Sumeru ; Asahi, Toru ; Lahav, Meir ; Kawasaki, Tsuneomi ; Soai, Kenso. / Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis. :: Organic and Biomolecular Chemistry. 2019 ; 巻 17, 番号 17. pp. 4200-4203.
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