Activation of the G protein Gq/11 through tyrosine phosphorylation of the α subunit

Hisashi Umemori, Takafumi Inoue, Shoen Kume, Naohiro Sekiyama, Motoshi Nagao, Hiroshi Itoh, Shigetada Nakanishi, Katsuhiko Mikoshiba, Tadashi Yamamoto

研究成果: Article査読

126 被引用数 (Scopus)

抄録

Various receptors coupled to the heterotrimeric guanine nucleotide- binding protein Gq/11 stimulate formation of inositol-1,4,5-trisphosphate (IP3). Activation of these receptors also induces protein tyrosine phosphorylation. Formation of IP3 in response to stimulated receptors that couple to Gq/11 was blocked by protein tyrosine kinase inhibitors. These inhibitors appeared to act before activation of Gq/11. Moreover, stimulation of receptors coupled to Gq/11 induced phosphorylation on a tyrosine residue (Tyr356) of the Gα(q/11) subunit, and this tyrosine phosphorylation event was essential for Gq/11 activation. Tyrosine phosphorylation of Gα(q/11) induced changes in its interaction with receptors. Therefore, tyrosine phosphorylation of Gα(q/11) appears to regulate the activation of Gq/11 protein.

本文言語English
ページ(範囲)1878-1881
ページ数4
ジャーナルScience
276
5320
DOI
出版ステータスPublished - 1997 6 20
外部発表はい

ASJC Scopus subject areas

  • 一般

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