Activation of vitronectin (serum spreading factor) binding of heparin by denaturing agents

Masao Hayashi*, Takao Akama, Ichiro Kono, Heihachiro Kashiwagi

*この研究の対応する著者

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Vitronectin (serum spreading factor), a cell-adhesive glycoprotein present in mammalian serum, has previously been the subject of conflicting reports concerning its binding to heparin. Vitronectin purified from human plasma does not bind to heparin under physiological conditions, but it does so after treatment with denaturing agents including 8 m urea or 6 m guanidine-HCl, or heating at 100°C for 5 min. These treatments seem to expose a heparin-binding site in vitronectin; this finding thus resolves the conflicts concerning this function.

本文言語English
ページ(範囲)1135-1138
ページ数4
ジャーナルJournal of biochemistry
98
4
DOI
出版ステータスPublished - 1985 10月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学

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