Activity of some atypical antidepressants on five models of muricide in rat

I. M.H. Al-Khatib, M. Fujiwara, S. Shibata, S. Ueki

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ9-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.

本文言語English
ページ(範囲)79-85
ページ数7
ジャーナルAsia Pacific Journal of Pharmacology
1
2
出版ステータスPublished - 1986 1 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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