Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men

David R. Broom, Masashi Miyashita, Lucy K. Wasse, Richard Pulsford, James A. King, Alice E. Thackray, David J. Stensel

研究成果: Article

19 引用 (Scopus)

抄録

Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52% peak oxygen uptake (VO2peak)) and VIG (36-min running at 75% VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70% VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.

元の言語English
ページ(範囲)411-422
ページ数12
ジャーナルJournal of Endocrinology
232
発行部数3
DOI
出版物ステータスPublished - 2017

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Ghrelin
Hunger
Running
Exercise
Energy Metabolism
Meals

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Broom, D. R., Miyashita, M., Wasse, L. K., Pulsford, R., King, J. A., Thackray, A. E., & Stensel, D. J. (2017). Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. Journal of Endocrinology, 232(3), 411-422. https://doi.org/10.1530/JOE-16-0561

Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. / Broom, David R.; Miyashita, Masashi; Wasse, Lucy K.; Pulsford, Richard; King, James A.; Thackray, Alice E.; Stensel, David J.

:: Journal of Endocrinology, 巻 232, 番号 3, 2017, p. 411-422.

研究成果: Article

Broom, DR, Miyashita, M, Wasse, LK, Pulsford, R, King, JA, Thackray, AE & Stensel, DJ 2017, 'Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men', Journal of Endocrinology, 巻. 232, 番号 3, pp. 411-422. https://doi.org/10.1530/JOE-16-0561
Broom, David R. ; Miyashita, Masashi ; Wasse, Lucy K. ; Pulsford, Richard ; King, James A. ; Thackray, Alice E. ; Stensel, David J. / Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. :: Journal of Endocrinology. 2017 ; 巻 232, 番号 3. pp. 411-422.
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abstract = "Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52{\%} peak oxygen uptake (VO2peak)) and VIG (36-min running at 75{\%} VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70{\%} VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.",
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AU - Broom, David R.

AU - Miyashita, Masashi

AU - Wasse, Lucy K.

AU - Pulsford, Richard

AU - King, James A.

AU - Thackray, Alice E.

AU - Stensel, David J.

PY - 2017

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N2 - Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52% peak oxygen uptake (VO2peak)) and VIG (36-min running at 75% VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70% VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.

AB - Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2.5 MJ induced in both MOD (55-min running at 52% peak oxygen uptake (VO2peak)) and VIG (36-min running at 75% VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70% VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P < 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P<0.001) and EX90 (ES = 0.68, P<0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5 h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.

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KW - Energy balance

KW - Exercise characteristics

KW - Exercise-induced anorexia

KW - Gut peptides

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