Acute exercise activates local bioactive androgen metabolism in skeletal muscle

Katsuji Aizawa, Motoyuki Iemitsu, Seiji Maeda, Takeshi Otsuki, Koji Sato, Takashi Ushida, Noboru Mesaki, Takayuki Akimoto*

*この研究の対応する著者

研究成果: Article査読

58 被引用数 (Scopus)

抄録

Androgens, such as testosterone, play important roles in regulation of diverse physiological process of target tissues. Recently, we reported that steroidogenic enzymes exist in skeletal muscle and regulate local production of testosterone in response to exercise. Testosterone is transformed into a bioactive androgen metabolite, dihydrotestosterone (DHT) by 5α-reductase. However, it is unclear whether exercise stimulates local bioactive androgen metabolism in the skeletal muscle in both sexes. In the present study, we examined sex differences in the levels of dehydroepiandrosterone (DHEA), free testosterone, DHT, and steroidogenesis-related enzymes 5α-reductase and androgen receptor (AR) in rat's skeletal muscle before and after a single bout of exercise. Basal muscular free testosterone and DHT levels were higher in males than females, whereas the levels of DHEA did not differ between the sexes. Muscular DHEA, free testosterone, and DHT levels were increased in both sexes after the exercise. There were no differences of 5α-reductase and AR transcripts and proteins between the sexes, and the expression of 5α-reductase was significantly increased in both sexes after the exercise. Finally, the expression of AR was significantly higher in female rats, but not in males after the exercise. These data suggest that acute exercise enhances the local bioactive androgen metabolism in the skeletal muscle of both sexes.

本文言語English
ページ(範囲)219-223
ページ数5
ジャーナルSteroids
75
3
DOI
出版ステータスPublished - 2010 3

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学
  • 薬理学
  • 臨床生化学
  • 有機化学

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