Acute high-intensity interval rowing increases thrombin generation in healthy men

Matthew J. Sedgwick, Matthew Thompson, Jack Garnham, Alice E. Thackray, Laura A. Barrett, Matthew Powis, David J. Stensel*

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Purpose: High-intensity exercise induces several health benefits, but may acutely and transiently increase the risk of cardiovascular events due to thrombotic changes promoting blood coagulation and thrombin formation. This study examined the effects of high-intensity exercise on plasma thrombin generation and triacylglycerol concentrations. Methods: Sixteen healthy men completed two, 2-day conditions separated by 1 week. On day 1, participants rested (control) or completed four, 3-min high-intensity rowing intervals at an average rating of perceived exertion of 17 (exercise). Venous blood samples were collected pre- and post-intervention to determine plasma thrombin generation. On day 2, participants rested and consumed a glucose load (0 h) and high-fat meal (2 h). Fifteen venous blood samples were collected between 0 and 8 h to measure plasma thrombin generation and triacylglycerol concentrations. Results: On day 1, lag time was shorter and peak thrombin and endogenous thrombin potential were greater in the exercise than control condition (ES ≥ 0.37, main effect condition P ≤ 0.03), and post-intervention compared with pre-intervention (ES ≥ 0.49, main effect time P ≤ 0.003). The magnitude of the post-intervention change was greater in the exercise than control condition for all thrombin generation parameters (condition by time interaction P ≤ 0.05). On day 2, no differences in postprandial thrombin generation parameters were seen between conditions (P ≥ 0.21). The total area under the curve for triacylglycerol was lower in the exercise than control condition (ES = 0.34, P = 0.02). Conclusion: An acute bout of high-intensity interval rowing increased plasma thrombin generation immediately after exercise, but these differences were eliminated 16–24 h after exercise.

本文言語English
ページ(範囲)1139-1148
ページ数10
ジャーナルEuropean Journal of Applied Physiology
116
6
DOI
出版ステータスPublished - 2016 6月 1
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 公衆衛生学、環境および労働衛生
  • 生理学(医学)

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