Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

Makoto Asai, Masayuki Ikeda, Masashi Akiyama, Itsuki Oshima, Shigenobu Shibata

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.

本文言語English
ページ(範囲)220-224
ページ数5
ジャーナルBrain Research
876
1-2
DOI
出版ステータスPublished - 2000 9 8

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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