@article{0b97340a8ff046e2a93e6e0193bf2787,
title = "Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8",
abstract = "We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (τ) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V.",
keywords = "Aging, Locomotor activity, Melatonin, Polymerase chain reaction",
author = "Makoto Asai and Masayuki Ikeda and Masashi Akiyama and Itsuki Oshima and Shigenobu Shibata",
note = "Funding Information: We would like to thank Dr Charles N. Allen (Oregon Health Sciences University) for helpful comments on this manuscript. This study was supported by Grants-in-Aid to S.S. from the Ministry of Education, Science, Sports and Culture of Japan and from Waseda University (96A-302).",
year = "2000",
month = sep,
day = "8",
doi = "10.1016/S0006-8993(00)02661-5",
language = "English",
volume = "876",
pages = "220--224",
journal = "Brain Research",
issn = "0006-8993",
number = "1-2",
}