Adsorption of taxol into ordered mesoporous silicas with various pore diameters

Hideo Hata, Shuuya Saeki, Tatsuo Kimura, Yoshiyuki Sugahara, Kazuyuki Kuroda*

*この研究の対応する著者

研究成果: Article査読

170 被引用数 (Scopus)

抄録

Taxol, an anticancer substance, was adsorbed into FSM-type mesoporous silicas with the pore sizes larger than 1.8 nm, while it was not adsorbed into the channels with the pore size less than 1.6 nm, indicating that mesoporous silicas have a molecular sieving property for relatively large molecules. The adsorption behavior of Taxol depended on the solvents; Taxol was not adsorbed into mesoporous silicas when methanol or acetone was used but was adsorbed when dichloromethane or toluene was used. The adsorption behavior of Taxol is discussed on the basis of the solubility parameters of the solvents. The proton-acceptor solubility parameter (δa) is a predominant factor in this liquid-solid partition system. The adsorption-desorption of an extract from yew needles was performed using the mesoporous silica and several elution solvents. In the adsorption, many components including Taxol were adsorbed into mesoporous silica. When the desorption of the extract components adsorbed into the mesoporous silica was performed with a mixture of methanol and water with varied ratios, the targeted molecule, Taxol, with a few addition of components was separated from the adsorbed components. This adsorption-desorption behavior was elucidated by the solubility parameter (δ) as well as δa.

本文言語English
ページ(範囲)1110-1119
ページ数10
ジャーナルChemistry of Materials
11
4
DOI
出版ステータスPublished - 1999 1月 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)
  • 材料化学

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