Aerobic exercise training normalizes central blood pressure regulation after oral glucose loading in overweight/obese men

Toru Yoshikawa, Hiroshi Kumagai, Kanae Myoenzono, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Central systolic blood pressure (cSBP) decreases after a meal or glucose challenge, but this response is impaired in obesity-related disorders. We investigated whether aerobic exercise training improves cSBP regulation during an oral glucose tolerance test (OGTT) in overweight/obese men. Thirteen overweight/obese men and six normal-weight men (as an alternative comparison instead of a no-exercise group) completed a 12-week aerobic exercise training program. Before and after the program, cSBP (i.e., radial second systolic pressure) was measured using an applanation tonometry at fasting and both 60 min and 120 min after 75 g glucose loading. Before and during the program, physical activity (PA) time was recorded using a tri-axial accelerometer. Pre-training, cSBP was significantly decreased with glucose loading in normal-weight men, while cSBP did not change in overweight/obese men. Post-training, a significant decrease in cSBP was observed in both groups following glucose loading. In addition, the increase in vigorous PA time during the exercise program was significantly correlated to the increase in area above the curve for cSBP during OGTT (demonstrating an improvement in the cSBP response to glucose loading) after the exercise program. These findings may provide novel insights into the role of PA in reducing the cardiovascular risk in obesity.

本文言語English
ページ(範囲)28-35
ページ数8
ジャーナルClinical and Experimental Hypertension
41
1
DOI
出版ステータスPublished - 2019 1 2
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 生理学

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