Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise.

Zsolt Radák*, Hae Young Chung, Hisashi Naito, Ryoya Takahashi, Kyung Jin Jung, Hyon Jeen Kim, Sataro Goto

*この研究の対応する著者

研究成果: Article査読

143 被引用数 (Scopus)

抄録

The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P<0.05). An age-associated increase in NF-kappaB activity was attenuated by the regular exercise. The content of p50 and p65 subunits of NF-kappaB increased with age and decreased with exercise training. The content of inhibitory factor-kappaB was inversely related to NF-kappaB activation. Regular exercise-induced adaptive responses, including attenuation of an increase in ROS production, LIPOX level, NF-kappaB activation, and reduced GSH/GSSG ratio, appear to be capable, even in old age, of reducing increases in inflammatory and other detrimental consequences that are often associated with advancing age.

本文言語English
ページ(範囲)749-750
ページ数2
ジャーナルThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
18
6
DOI
出版ステータスPublished - 2004 4
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生化学
  • 分子生物学
  • 遺伝学

フィンガープリント

「Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル