Age differences in the relation between ACTN3 R577X polymorphism and thigh-muscle cross-sectional area in women.

Hirofumi Zempo*, Kai Tanabe, Haruka Murakami, Motoyuki Iemitsu, Seiji Maeda, Shinya Kuno

*この研究の対応する著者

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The relation between ACTN3 R577X polymorphism and muscle mass in women has been reported, but its relation to age remains unclear. We investigated the relationship between ACTN3 R577X polymorphism and muscle mass in both middle-aged and elderly women. Two age groups (middle-aged and older) were formed among 162 healthy, nontraining Japanese women (mean ± SE, 58.6 ± 0.8 year). Their midthigh-muscle cross-sectional area (CSA) was assessed using magnetic resonance imaging, revealing no difference in thigh-muscle CSA among ACTN3 R577X genotypes in the middle-aged group (XX, 87.3 ± 2.5 cm(2); RR&RX, 86.1 ± 1.7 cm(2), p=0.7). In contrast, the XX genotype in the older group had a smaller thigh-muscle CSA adjusted to body weight than the RR&RX genotypes (XX, 67.8 ± 2.0 cm(2); RR&RX, 72.5 ± 1.2 cm(2), p<0.05). The present study showed an association between ACTN3 R577X polymorphism and smaller thigh-muscle CSA in a group of elderly women but not in a group of middle-aged women.

本文言語English
ページ(範囲)639-643
ページ数5
ジャーナルGenetic Testing and Molecular Biomarkers
15
9
DOI
出版ステータスPublished - 2011 9
外部発表はい

ASJC Scopus subject areas

  • 遺伝学(臨床)

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