Age-related reduction of systemic arterial compliance relates to decreased aerobic capacity during sub-maximal exercise

Takeshi Otsuki, Seiji Maeda, Jun Sugawara, Yumiko Kesen, Haruka Murakami, Takumi Tanabe, Takashi Miyauchi, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda*

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

A decrease in systemic arterial compliance (SAC) increases left ventricular load along with the demand for excessive myocardial oxygen consumption when the age-related reduction of SAC reaches a marked level, and consequently may depress left ventricular pump function. Reduced left ventricular pump function decreases aerobic capacity, and some study groups have shown that SAC and/or central arterial distensibility is correlated with maximal aerobic capacity in humans. We thus hypothesize that, once the age-related reduction of SAC reaches a marked level, the participation of SAC in aerobic capacity will be significant even during sub-maximal exercise. Thirty young humans and 46 elderly humans participated in this study. SAC, oxygen uptake at the ventilatory threshold (V̇o2VT), and the ratio of increase in oxygen uptake, in cardiac output, and in effective arterial elastance to increase in work rate (Δ V̇o2/ΔWR, ΔCO/ΔWR and ΔEa/ΔWR) were measured. SAC was significantly higher in young subjects compared with elderly subjects, and was significantly related to V̇o2VT in elderly subjects. SAC also significantly correlated with ΔV̇o2/ΔWR, ΔCO/ ΔWR and ΔE/aΔWR in elderly subjects. When total subjects were divided by the value of SAC into 6 groups, the V̇o2VT values in the 3 groups with lower SAC were significantly lower than those in the 3 groups with higher SAC, and gradually decreased with the reduction of SAC. There were no changes in V̇o2VT among the 3 groups with higher SAC. These results suggest that the participation of SAC in aerobic capacity is significant even during sub-maximal exercise in individuals who show a pronounced age-related reduction of SAC.

本文言語English
ページ(範囲)759-765
ページ数7
ジャーナルHypertension Research
29
10
DOI
出版ステータスPublished - 2006 10
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学

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