TY - JOUR
T1 - Ageing affects the association between serum 25- hydroxyvitamin D concentrations and cardiorespiratory fitness in middle-aged and elderly men
AU - Sun, Xiaomin
AU - Kumpei, Tanisawa
AU - Ito, Tomoko
AU - Oshima, Satomi
AU - Higuchi, Mitsuru
AU - Cao, Zhen Bo
N1 - Funding Information:
This study was funded partly by a grant-in-aid for the Global COE Program (Sport Sciences for the Promotion of Active Life to Waseda University) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to MH); a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to ZBC); and grants from National Natural Science Foundation of China (No. 31571226 and No. 81703220).
Publisher Copyright:
© 2019. All Rights Reserved.
PY - 2019/9
Y1 - 2019/9
N2 - The studies investigated the association between serum 25 hydroxyvitamin D (25(OH)D) concentrations and cardiorespiratory fitness (CRF) are few, and the results are controversial. We aim to evaluate the association of serum 25(OH)D concentrations with CRF in adults, and assess whether the associations vary with ageing. Methods and Study Design: The study included 78 middle-aged (30-64 years) and 83 elderly (65-79 years) Japanese men. Hand grip strength and leg extension power were measured using hand grip and leg dynamometers, respectively. CRF was measured via a maximal graded exercise test and quantified as the peak oxygen uptake (VO2peak). Fasting serum 25(OH)D concentrations were determined by enzyme-linked immunosorbant assay. Results: Serum 25(OH)D concentrations were positively related to hand grip strength (r=0.331, p<0.001), leg extension power (r=0.353, p<0.001), CRF (r=0.285, p<0.001) in all adults after adjustment for age. Significant interaction between 25(OH)D and age on CRF was observed (p<0.05). Age related reduction of CRF was prevented in high 25(OH)D group (p<0.05). In the elderly, subjects in high 25(OH)D group had higher CRF compared with those in low group (p<0.05).(p<0.05).
AB - The studies investigated the association between serum 25 hydroxyvitamin D (25(OH)D) concentrations and cardiorespiratory fitness (CRF) are few, and the results are controversial. We aim to evaluate the association of serum 25(OH)D concentrations with CRF in adults, and assess whether the associations vary with ageing. Methods and Study Design: The study included 78 middle-aged (30-64 years) and 83 elderly (65-79 years) Japanese men. Hand grip strength and leg extension power were measured using hand grip and leg dynamometers, respectively. CRF was measured via a maximal graded exercise test and quantified as the peak oxygen uptake (VO2peak). Fasting serum 25(OH)D concentrations were determined by enzyme-linked immunosorbant assay. Results: Serum 25(OH)D concentrations were positively related to hand grip strength (r=0.331, p<0.001), leg extension power (r=0.353, p<0.001), CRF (r=0.285, p<0.001) in all adults after adjustment for age. Significant interaction between 25(OH)D and age on CRF was observed (p<0.05). Age related reduction of CRF was prevented in high 25(OH)D group (p<0.05). In the elderly, subjects in high 25(OH)D group had higher CRF compared with those in low group (p<0.05).(p<0.05).
KW - advancing age
KW - cardiorespiratory fitness
KW - hand grip strength
KW - leg extension power
KW - vitamin D
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U2 - 10.6133/apjcn.201909_28
DO - 10.6133/apjcn.201909_28
M3 - Article
C2 - 31464409
AN - SCOPUS:85071651246
SN - 0964-7058
VL - 28
SP - 614
EP - 620
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
IS - 3
ER -