AIM-1: A mammalian midbody-associated protein required for cytokinesis

Yasuhiko Terada*, Masaaki Tatsuka, Fumio Suzuki, Yuko Yasuda, Setsuya Fujita, Masayuki Otsu

*この研究の対応する著者

研究成果: Article査読

363 被引用数 (Scopus)

抄録

Mitosis is a highly coordinated process that assures the fidelity of chromosome segregation. Errors in this process result in aneuploidy which can lead to cell death or oncogenesis. In this paper we describe a putative mammalian protein kinase, AIM-1 (Aurora and Ip11-like midbody-associated protein), related to Drosophila Aurora and Saccharomyces cerevisiae Ip11, both of which are required for chromosome segregation. AIM-1 message and protein accumulate at G2/M phase. The protein localizes at the equator of central spindles during late anaphase and at the midbody during telophase and cytokinesis. Overexpression of kinase-inactive AIM-1 disrupts cleavage furrow formation without affecting nuclear division. Furthermore, cytokinesis frequently fails, resulting in cell polyploidy and subsequent cell death. These results strongly suggest that AIM-1 is required for proper progression of cytokinesis in mammalian cells.

本文言語English
ページ(範囲)667-676
ページ数10
ジャーナルEMBO Journal
17
3
DOI
出版ステータスPublished - 1998 2 2
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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