Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499

Kazunari Sakai, Masato Iwatsuki, Masato Iizuka, Yukihiro Asami, Kenichi Nonaka, Rokuro Masuma, Mami Takizawa, Takuji Nakashima, Toshiyuki Tokiwa, Kazuro Shiomi, Satoshi Ōmura

研究成果: Article査読

抄録

An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.

本文言語English
ページ(範囲)363-369
ページ数7
ジャーナルJournal of Antibiotics
74
6
DOI
出版ステータスPublished - 2021 6
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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