Alkylation of pyridine‐3,5‐dicarboxamide and pyridine‐3,5‐dicarbonitriles by radical substitution

Nobuhiro Kanomata, Hisashi Nagahara, Masaru Tada

    研究成果: Article査読

    抄録

    Structural modification of NAD(P) model compounds, N,N,N',N'‐tetramethylpyridine‐3,5‐dicarboxamide (1), pyridine‐3,5‐dicarbonitrile (2), and 4‐methylpyridine‐3,5‐dicarbonitrile (3), have been explored by the reaction with alkyl radicals such as the 1‐adamantyl, tert‐butyl, and isopropyl radicals. The alkyl substitutions of compounds 1, 2, and 3 with the 1‐adamantyl and the tert‐butyl radical gave both 2‐mono and 2,6‐disubstitution products, whereas the reaction of compound 2 with the isopropyl radical gave 2‐mono 6c, 2,4‐di 7c, 2,6‐di 8c, and 2,4,6‐trisubstitution 9c products.

    本文言語English
    ページ(範囲)1567-1571
    ページ数5
    ジャーナルJournal of Heterocyclic Chemistry
    29
    6
    DOI
    出版ステータスPublished - 1992

    ASJC Scopus subject areas

    • Organic Chemistry

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