Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter

Keiichi Amano*, Koiti Kitamura, Hirotsune Kawamura, Tatsuya Tanikawa, Hiroko Kawabatake, Masao Notani, Hiroshi Iseki, Telsusi Shiwaku, Toshihiro Suda, Hiroshi Demura

*この研究の対応する著者

    研究成果: Article査読

    12 被引用数 (Scopus)

    抄録

    Immunoreactive beta-endorphin in the third ventricular fluid was measured in response to electrical stimulation of the periaqueductal gray matter in 8 patients with intractable pain during rostral mesencephalic reticulotomy for pain relief. In all patients, marked increase of immunoreactive beta-endorphin was observed. On the other hand, in cases of electrical stimulation of the zona incerta performed during stereoencephalotomy, in 5 patients with involuntary movement, immunoreactive beta-endorphin in the third ventricular fluid did not show any significant change. The authors conclude that the increase of immunoreactive bcta-endor- phin on electrical stimulation of the periaqueductal gray matter is not a nonspecific response to brain stimulation but a specific response in regard to cerebral localization of endorphins. Direct correlation between pain relief and periaqueductal gray stimulation is also questioned.

    本文言語English
    ページ(範囲)150-158
    ページ数9
    ジャーナルStereotactic and Functional Neurosurgery
    43
    3-5
    DOI
    出版ステータスPublished - 1980

    ASJC Scopus subject areas

    • 外科
    • 臨床神経学

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