Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter

Keiichi Amano, Koiti Kitamura, Hirotsune Kawamura, Tatsuya Tanikawa, Hiroko Kawabatake, Masao Notani, Hiroshi Iseki, Telsusi Shiwaku, Toshihiro Suda, Hiroshi Demura

    研究成果: Article査読

    12 被引用数 (Scopus)

    抄録

    Immunoreactive beta-endorphin in the third ventricular fluid was measured in response to electrical stimulation of the periaqueductal gray matter in 8 patients with intractable pain during rostral mesencephalic reticulotomy for pain relief. In all patients, marked increase of immunoreactive beta-endorphin was observed. On the other hand, in cases of electrical stimulation of the zona incerta performed during stereoencephalotomy, in 5 patients with involuntary movement, immunoreactive beta-endorphin in the third ventricular fluid did not show any significant change. The authors conclude that the increase of immunoreactive bcta-endor- phin on electrical stimulation of the periaqueductal gray matter is not a nonspecific response to brain stimulation but a specific response in regard to cerebral localization of endorphins. Direct correlation between pain relief and periaqueductal gray stimulation is also questioned.

    本文言語English
    ページ(範囲)150-158
    ページ数9
    ジャーナルStereotactic and Functional Neurosurgery
    43
    3-5
    DOI
    出版ステータスPublished - 1980

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology

    フィンガープリント 「Alterations of immunoreactive beta-endorphin in the third ventricular fluid in response to electrical stimulation of the human periaqueductal gray matter」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル