@article{75d8616793894d9b9e305cf92740a345,
title = "Amoxicillin vs third-generation cephalosporin for infection prophylaxis after third molar extraction",
abstract = "Objectives: Although amoxicillin is the first-line prophylactic drug for impacted mandibular third molar extraction, third-generation cephalosporins are widely prescribed in Japan. The lack of real-world evidence may be one reason for this inappropriate use. We evaluated differences in the incidence of surgical site infection between amoxicillin and third-generation cephalosporins for impacted mandibular third molar extraction. Methods: Using the JMDC Claims Database, we identified dental visits with fully or horizontally impacted mandibular third molar extraction from April 2015 to March 2020. One-to-one propensity-score matching was conducted between amoxicillin and third-generation cephalosporin groups. The incidence of surgical site infection following extraction was compared in the matched pairs using McNemar's test. Results: We identified 109,266 dental visits, including 39,514 (36.2%) patients who received amoxicillin and 69,752 (63.8%) patients who received third-generation cephalosporins. In the 39,514 matched pairs, the incidence of surgical site infection was 3.5% (n = 1399) for amoxicillin group and 3.7% (n = 1467) for third-generation cephalosporin group (p = 0.003). Conclusions: Amoxicillin was associated with a lower incidence of surgical site infection after impacted mandibular third molar extraction compared with third-generation cephalosporins. This result supports current guidelines and strengthens the importance of disseminating and implementing antimicrobial resistance control in dentistry.",
keywords = "antimicrobial resistance, impacted mandibular third molar, propensity-score matching, surgical site infection prophylaxis, tooth extraction",
author = "Misuzu Sato and Hayato Yamana and Sachiko Ono and Miho Ishimaru and Hiroki Matsui and Hideo Yasunaga",
note = "Funding Information: This work was supported by grants from the Ministry of Health, Labour and Welfare, Japan (21AA2007) and the Ministry of Education, Culture, Sports, Science and Technology, Japan (19K10419, 20H03907, and 21H03159). Funding Information: This work was supported by grants from the Ministry of Health, Labour and Welfare, Japan (21AA2007) and the Ministry of Education, Culture, Sports, Science and Technology, Japan (19K10419, 20H03907, and 21H03159). H. Yamana has an academic affiliation with the Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, which is supported by Tsumura & Company. S. Ono has an academic affiliation with the Department of Eat‐loss Medicine, Graduate School of Medicine, The University of Tokyo, which is supported by ITO EN. Tsumura & Company and ITO EN played no role in the design of the study; the collection, analysis, or interpretation of the data; the writing of the manuscript; or the decision to publish the results. The authors would like to thank Dr. Takaaki Konishi and Dr. Akira Okada of the University of Tokyo and Dr. Shunichi Otaka of the International University of Health and Welfare for their advice on data analysis and interpretation. Funding Information: H. Yamana has an academic affiliation with the Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, which is supported by Tsumura & Company. S. Ono has an academic affiliation with the Department of Eat‐loss Medicine, Graduate School of Medicine, The University of Tokyo, which is supported by ITO EN. Tsumura & Company and ITO EN played no role in in the design of the study; the collection, analysis, or interpretation of the data; the writing of the manuscript; or the decision to publish the results. Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",
year = "2022",
doi = "10.1111/odi.14421",
language = "English",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
}