An attempt to reveal a role of a transcription/translation feedback loop in the cyanobacterial KaiC protein-based circadian system by using a semi-synthetic method

Hirokazu Tozaki, Taiichiro Kobe, Kazuyuki Aihara, Hideo Iwasaki*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The use of synthetic biology to design artificial gene circuits is an important approach for understanding the principles underlying the complicated dynamic behaviours of biomolecular networks, such as genetic switching and biological rhythms. The synthetic approach is also useful in systems biology in that it can be used to create artificial bypasses for processes related to cellular phenomena of interest for their easier analysis. To validate the role of transcription feedback in the cyanobacterial circadian system, we propose an experimental design for a 'semi-synthetic' approach that involves transplantation of the kaiABC genes into Escherichia coli and the construction of chimeric transcriptional outputs. The design principle and preliminary results are discussed.

本文言語English
ページ(範囲)435-444
ページ数10
ジャーナルInternational Journal of Bioinformatics Research and Applications
4
4
DOI
出版ステータスPublished - 2008 11

ASJC Scopus subject areas

  • 生体医工学
  • 健康情報学
  • 臨床生化学
  • 健康情報管理

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