Analysis of Morphological Changes in Monosodium Urate Monohydrate Crystals for Gout Treatment

Momoko Oda, Izumi Hirasawa*, Fukashi Kohori

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Gout is arthritis induced by monosodium urate monohydrate (MSU) crystals. The treatment of gout is mainly a symptomatic treatment, by suppressing the blood uric acid concentration with drugs. Here, the changes in crystal morphology in the process of MSU crystallization were investigated. Experiments were conducted to clarify the mechanisms of nucleation and growth of the MSU crystals, revealing that MSU first precipitated as granular crystals. Thereafter, nucleation and growth of needle-like crystals were observed concomitant with the disappearance of the granular crystals. These results suggest that it is necessary to suppress the nucleation of granular crystals and the change in morphology from granular to needle-like of the MSU crystals that cause gout.

本文言語English
ページ(範囲)1087-1092
ページ数6
ジャーナルChemical Engineering and Technology
43
6
DOI
出版ステータスPublished - 2020 6 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)
  • 産業および生産工学

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