Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Rob W.M. Van Soest, Nobuhiro Fusetani*

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).1 Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC50 values of 180-500 μg/mL.

本文言語English
ページ(範囲)1229-1234
ページ数6
ジャーナルTetrahedron
57
7
DOI
出版ステータスPublished - 2001 2 11
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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