Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele

Masaki Fujita, Youichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Rob W M Van Soest, Nobuhiro Fusetani

研究成果: Article

37 引用 (Scopus)

抄録

Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).1 Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC50 values of 180-500 μg/mL.

元の言語English
ページ（範囲）1229-1234
ページ数6
ジャーナルTetrahedron
巻57
発行部数7
DOI
出版物ステータスPublished - 2001 2 11
外部発表Yes

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Matrix Metalloproteinase 14
Porifera
Glycosides
Inhibitory Concentration 50
tetramic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

これを引用

Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele. / Fujita, Masaki; Nakao, Youichi; Matsunaga, Shigeki; Seiki, Motoharu; Itoh, Yoshifumi; Van Soest, Rob W M; Fusetani, Nobuhiro.

：: Tetrahedron, 巻 57, 番号 7, 11.02.2001, p. 1229-1234.

研究成果: Article

Fujita, M, Nakao, Y, Matsunaga, S, Seiki, M, Itoh, Y, Van Soest, RWM & Fusetani, N 2001, 'Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele', Tetrahedron, 巻. 57, 番号 7, pp. 1229-1234. https://doi.org/10.1016/S0040-4020(00)01128-5
Fujita M, Nakao Y, Matsunaga S, Seiki M, Itoh Y, Van Soest RWM その他. Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele. Tetrahedron. 2001 2 11;57(7):1229-1234. https://doi.org/10.1016/S0040-4020(00)01128-5
Fujita, Masaki ; Nakao, Youichi ; Matsunaga, Shigeki ; Seiki, Motoharu ; Itoh, Yoshifumi ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele. ：: Tetrahedron. 2001 ; 巻 57, 番号 7. pp. 1229-1234.
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T1 - Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele

AU - Fujita, Masaki

AU - Nakao, Youichi

AU - Matsunaga, Shigeki

AU - Seiki, Motoharu

AU - Itoh, Yoshifumi

AU - Van Soest, Rob W M

AU - Fusetani, Nobuhiro

PY - 2001/2/11

Y1 - 2001/2/11

N2 - Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).1 Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC50 values of 180-500 μg/mL.

AB - Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).1 Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC50 values of 180-500 μg/mL.

KW - Biologically active compounds

KW - Enzyme inhibitors

KW - Marine metabolites

KW - Sponges

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DO - 10.1016/S0040-4020(00)01128-5

M3 - Article

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JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

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ER -

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